El cepillado protegido bacteriológico en pacientes con EPOC severa
The protected specimen brush technique in patients with severe chronic obstructive pulmonary disease
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Sobradillo" "autores" => array:5 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Zalacain" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "V." "apellidos" => "Achótegui" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Pascal" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Camino" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Sobradillo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicios de Neumología, Hospital de Cruces. Vizcaya" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Servicio de Neumología. Hospital de Cruces. 48903 Cruces. Baracaldo." ] ] ] 1 => array:3 [ "autoresLista" => "J. Barrón" "autores" => array:1 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Barrón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicios de Microbiología. Hospital de Cruces. Vizcaya" "etiqueta" => "*" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The protected specimen brush technique in patients with severe chronic obstructive pulmonary disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1996-02-27" "fechaAceptado" => "1996-05-21" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec545587" "palabras" => array:2 [ 0 => "Enfermedad pulmonar obstructiva crónica (EPOC)" 1 => "Cepillado protegido" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec545586" "palabras" => array:2 [ 0 => "Chronic obstructive pulmonary disease (COPD)" 1 => "Protected specimen brush" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio ha sido conocer mediante el empleo de una técnica de alta Habilidad cómo es el catéter teleescopado con cepillado bacteriológico (CT), la presencia de gérmenes y su concentración en un grupo de pacientes con EPOC severa (FEV<span class="elsevierStyleInf">1</span> < 50%), unos en fase de estabilización clínica y otros con datos clínicos de agudización.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 26 pacientes con EPOC severa, 14 estables y 12 agudizados. Ninguno había recibido tratamiento previo con antibióticos o corticoides. Los estables no tenían ningún dato clínico de exacerbación y los agudizados tenían aumento de disnea, del volumen del esputo y de la purulencia del mismo. El CT se realizó con anestesia en aerosol, sin emplear anestesia líquida. Se consideró el CT positivo cuando había ≥ 10<span class="elsevierStyleSup">3</span> UFC/ml.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">No hubo diferencias entre los grupos en cuanto a edad, sexo, proporción de fumadores y ex fumadores, y paquetes/ año. En los valores espirométricos tampoco hubo diferencias salvo en la relación FEV<span class="elsevierStyleInf">1</span>/CVF que fue menor en los agudizados (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05). El CT fue positivo en el 57,1% de los estables y en el 66,7% de los agudizados (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS). H. influenwe fue el microorganismo hallado en mayor número en ambos grupos. El número medio de UFC/ml fue de 8.625 en los estables y 17.375 en los agudizados (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS).</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Un elevado número de pacientes (57,1%) con EPOC severa en fase de estabilización clínica presentaron gérmenes en concentraciones significativas mediante el empleo de CT. Por otro lado, con esta misma técnica, en otro grupo de pacientes con EPOC severa, de similares características, pero con datos clínicos de agudización, se hallaron gérmenes en el 66,7% no siendo la diferencia significativa, y se confirmó la falta de correlación clínico-bacteriológica.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the presence of germs and their concentratfon in a group of patients with severe chronic obstructive pulmonary disease (COPD) (FEV<span class="elsevierStyleInf">1</span> < 50%), some of whom were in stable condition and others of whom were in acute phase.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Twenty-six patients with severe COPD (14 stable and 12 acute phase) were enrolled. None had received prior antibiotic or corticoid treatment. The stable patients had no signs or symptoms of exacerbation, whereas the acute-phase patients had increased dyspnea, sputum volume and purulence. The patients received aerosol rather than liquid anesthesia when PSB sampling was performed. A PSB fínding was considered positive at a level ≥ 10<span class="elsevierStyleSup">3</span><span class="elsevierStyleHsp" style=""></span>CFU/ml.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">There were no significant differences between the groups with respect to age, sex, proportion of smokers and ex-smokers or packs per year. The oniy spirometric measure that was significantly different was (FEV<span class="elsevierStyleInf">1</span>/FVC, which was lower in the acute-phase group (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). Positive PSB findings were recorded for 57.1% of the stable patients and for 66.7% of the acute-phase patients (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS). <span class="elsevierStyleItalic">H.influenzae</span> was the microorganism found most often in both groups. The mean CFU/ml level was 8,625 in stable patients and 17,375 in acute-phase patients (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS).</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A large proportion of stable patients (57.1%) with severe COPD harbor significant concentrations of germs as revealed by PSB sampling. Germ concentrations were found in a non significantly greater number of acute-phase patients, confirming the lack of congruence between clinical status and bacteriological condition.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bacterial infection in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.F. Murphy" 1 => "S. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 39 | 16 | 55 |
| 2024 September | 30 | 31 | 61 |
| 2024 August | 58 | 40 | 98 |
| 2024 July | 29 | 29 | 58 |
| 2024 June | 39 | 27 | 66 |
| 2024 May | 48 | 26 | 74 |
| 2024 April | 33 | 37 | 70 |
| 2024 March | 37 | 25 | 62 |
| 2024 February | 27 | 33 | 60 |
| 2024 January | 0 | 13 | 13 |
| 2023 December | 0 | 1 | 1 |
| 2023 November | 0 | 3 | 3 |
| 2023 October | 0 | 4 | 4 |
| 2023 September | 0 | 5 | 5 |
| 2023 August | 0 | 8 | 8 |
| 2023 July | 0 | 4 | 4 |
| 2023 June | 0 | 1 | 1 |
| 2023 April | 0 | 2 | 2 |
| 2023 March | 2 | 2 | 4 |
| 2023 February | 28 | 27 | 55 |
| 2023 January | 21 | 27 | 48 |
| 2022 December | 28 | 26 | 54 |
| 2022 November | 38 | 10 | 48 |
| 2022 October | 25 | 31 | 56 |
| 2022 September | 24 | 18 | 42 |
| 2022 August | 28 | 36 | 64 |
| 2022 July | 25 | 36 | 61 |
| 2022 June | 20 | 36 | 56 |
| 2022 May | 33 | 31 | 64 |
| 2022 April | 19 | 34 | 53 |
| 2022 March | 31 | 27 | 58 |
| 2022 February | 38 | 28 | 66 |
| 2022 January | 22 | 26 | 48 |
| 2021 December | 22 | 33 | 55 |
| 2021 November | 17 | 33 | 50 |
| 2021 October | 19 | 24 | 43 |
| 2021 September | 30 | 39 | 69 |
| 2021 August | 14 | 27 | 41 |
| 2021 July | 25 | 31 | 56 |
| 2021 June | 19 | 27 | 46 |
| 2021 May | 15 | 25 | 40 |
| 2021 April | 28 | 59 | 87 |
| 2021 March | 35 | 21 | 56 |
| 2021 February | 24 | 20 | 44 |
| 2021 January | 15 | 17 | 32 |
| 2020 December | 20 | 8 | 28 |
| 2020 November | 14 | 14 | 28 |
| 2020 October | 10 | 13 | 23 |
| 2020 September | 19 | 16 | 35 |
| 2020 August | 14 | 24 | 38 |
| 2020 July | 18 | 13 | 31 |
| 2020 June | 23 | 10 | 33 |
| 2020 May | 21 | 7 | 28 |
| 2020 April | 22 | 7 | 29 |
| 2020 March | 21 | 17 | 38 |
| 2020 February | 22 | 20 | 42 |
| 2020 January | 45 | 21 | 66 |
| 2019 December | 27 | 27 | 54 |
| 2019 November | 15 | 11 | 26 |
| 2019 October | 26 | 13 | 39 |
| 2019 September | 17 | 29 | 46 |
| 2019 August | 13 | 9 | 22 |
| 2019 July | 14 | 39 | 53 |
| 2019 June | 12 | 33 | 45 |
| 2019 May | 25 | 32 | 57 |
| 2019 April | 45 | 33 | 78 |
| 2019 March | 19 | 27 | 46 |
| 2019 February | 19 | 17 | 36 |
| 2019 January | 16 | 19 | 35 |
| 2018 December | 12 | 15 | 27 |
| 2018 November | 24 | 16 | 40 |
| 2018 October | 30 | 17 | 47 |
| 2018 September | 18 | 15 | 33 |
| 2018 May | 6 | 1 | 7 |
| 2018 April | 10 | 5 | 15 |
| 2018 March | 6 | 5 | 11 |
| 2018 February | 8 | 7 | 15 |
| 2018 January | 9 | 6 | 15 |
| 2017 December | 6 | 10 | 16 |
| 2017 November | 5 | 5 | 10 |
| 2017 October | 7 | 10 | 17 |
| 2017 September | 6 | 12 | 18 |
| 2017 August | 10 | 10 | 20 |
| 2017 July | 5 | 6 | 11 |
| 2017 June | 12 | 13 | 25 |
| 2017 May | 9 | 11 | 20 |
| 2017 April | 6 | 4 | 10 |
| 2017 March | 9 | 10 | 19 |
| 2017 February | 4 | 7 | 11 |
| 2017 January | 3 | 3 | 6 |
| 2016 December | 15 | 13 | 28 |
| 2016 November | 22 | 15 | 37 |
| 2016 October | 19 | 15 | 34 |
| 2016 September | 17 | 11 | 28 |
| 2016 August | 18 | 9 | 27 |
| 2016 July | 21 | 2 | 23 |
| 2016 June | 24 | 9 | 33 |
| 2016 May | 11 | 5 | 16 |
| 2016 April | 25 | 0 | 25 |
| 2016 March | 12 | 1 | 13 |
| 2016 February | 16 | 1 | 17 |
| 2016 January | 23 | 6 | 29 |
| 2015 December | 25 | 12 | 37 |
| 2015 November | 32 | 2 | 34 |
| 2015 October | 6 | 1 | 7 |
| 2015 September | 1 | 0 | 1 |
| 2015 June | 1 | 0 | 1 |
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